Acmella Uliginosa: Farmakologi, Fitokimia, Toksikologi dan Perkembangan Analog: Review Artikel
DOI:
https://doi.org/10.60010/jikd.v4i2.82Keywords:
Acmella Uliginosa, Farmakologi, Fitokimia, Pengembangan ObatAbstract
Acmella uliginosa is an important medicinal plant, it is found in tropical and subtropical countries especially Indonesia, India and South America. This plant known as a toothache plant which is usually used to reduce pain associated with toothache. Various extracts and active metabolites from various parts of this plant have beneficial pharmacological activities. Several studies show Acmella Uliginosa has pharmacological activities such as antimicrobial, antipyretic, antioxidant, and anti-inflammatory. This review in detail describes the traditional uses, phytochemicals, pharmacology, toxicology and development of analogues of the active constituents of this plant. This review will help researchers to find scientific information in the future.
Acmella Uliginosa adalah tanaman obat penting, ditemukan di negara-negara tropis dan subtropis terutama Indonesia, India dan Amerika Selatan. Tanaman ini dikenal sebagai tanaman sakit gigi yang biasanya digunkan untuk mengurangi rasa sakit yang berhubungan dengan sakit gigi. Bermacam-macam ekstrak dan metabolit aktif dari berbagai bagian tanaman ini memiliki aktivitas farmakologis yang bermanfaat. Beberapa penelitian menyebutkan Acmella Uliginosa memiliki aktivitas farmakologi seperti antimikroba, antipiretik, antioksidan, dan antiinflamasi. Ulasan ini secara rinci menggambarkan penggunaan tradisional, fitokimia, farmakologi, toksikologi dan perkembangan analog dari konstituen aktiv tanaman ini. Review ini akan membantu peneliti untuk mencari informasi ilmiah di masa depan.
References
Devi K, L., 2017. Total Phenolic Content and Antioxidant Activity of Spilanthes Species from Peninsular India. Int J Pharm Pharmacol 1, 1–6. https://doi.org/10.31531/2581-3080.1000115
Elufioye, T.O., Habtemariam, S., Adejare, A., 2020. Chemistry and Pharmacology of Alkylamides from Natural Origin. Rev. Bras. Farmacogn. 30, 622–640. https://doi.org/10.1007/s43450-020-00095-5
Hijir, A.S., Salni, S., Marwoto, J., Triwani, T., Nita, S., Saleh, M.I., Maritska, Z., Parisa, N., Lusiana, E., Tamzil, N.S., Rosdah, A.A., 2017. Antifungi Effect of Keghenyat Leaves Fraction (Acmella uliginosa) In Vitro Study. 1 1, 1–7. https://doi.org/10.32539/bsm.v1i1.5
Lagnika, L., Amoussa, A.M.O., Adjileye, R.A.A., Laleye, A., Sanni, A., 2016a. Antimicrobial, antioxidant, toxicity and phytochemical assessment of extracts from Acmella uliginosa, a leafy-vegetable consumed in Bénin, West Africa. BMC Complementary and Alternative Medicine 16, 34. https://doi.org/10.1186/s12906-016-1014-3
Lagnika, L., Amoussa, A.M.O., Adjileye, R.A.A., Laleye, A., Sanni, A., 2016b. Antimicrobial, antioxidant, toxicity and phytochemical assessment of extracts from Acmella uliginosa, a leafy-vegetable consumed in Bénin, West Africa. BMC Complement Altern Med 16, 34. https://doi.org/10.1186/s12906-016-1014-3
Lalthanpuii, P.B., Sailo, N., Lalruatfela, B., Lalremsanga, H.T., Lalchhandama, K., 2019. Some Phytochemical, Antimicrobial and Anticancer Tests for an Aqueous extract of Acmella oleracea. Research Journal of Pharmacy and Technology 12, 3033–3037. https://doi.org/10.5958/0974-360X.2019.00513.4
Maimulyanti, A., Prihadi, A.R., 2016. Chemical composition of essential oil and hexane extract and antioxidant activity of various extracts of Acmella uliginosa (Sw.) Cass flowers from Indonesia. Agriculture and Natural Resources 50, 264–269. https://doi.org/10.1016/j.anres.2015.11.002
Maimulyanti, A., Prihadi, A.R., Safrudin, I., 2018. Chemical Composition, Phytochemical Screening and Antioxidant Activity of Acmella uliginosa (Sw.) Cass Leaves. Indones. J. Chem. 16, 162. https://doi.org/10.22146/ijc.21160
Meyer, B., Ferrigni, N., Putnam, J., Jacobsen, L., Nichols, D., McLaughlin, J., 1982. Brine Shrimp: A Convenient General Bioassay for Active Plant Constituents. Planta Med 45, 31–34. https://doi.org/10.1055/s-2007-971236
Norsafinah, N., Diyanah, N., Munirah, 2016. Evaluation of anti-inflammatory potentiality of Plant based Bio-active Compounds [WWW Document]. ResearchGate. URL https://www.researchgate.net/project/Evaluation-of-anti-inflammatory-potentiality-of-Plant-based-Bio-active-Compounds (accessed 1.22.22).
Ong, H.M., Mohamad, A.S., Makhtar, N. ‘Adilah, Khalid, M.H., Khalid, S., Perimal, E.K., Mastuki, S.N., Zakaria, Z.A., Lajis, N., Israf, D.A., Sulaiman, M.R., 2011a. Antinociceptive activity of methanolic extract of Acmella uliginosa (Sw.) Cass. Journal of Ethnopharmacology 133, 227–233. https://doi.org/10.1016/j.jep.2010.09.030
Ong, H.M., Mohamad, A.S., Makhtar, N. ’Adilah, Khalid, M.H., Khalid, S., Perimal, E.K., Mastuki, S.N., Zakaria, Z.A., Lajis, N., Israf, D.A., Sulaiman, M.R., 2011b. Antinociceptive activity of methanolic extract of Acmella uliginosa (Sw.) Cass. J Ethnopharmacol 133, 227–233. https://doi.org/10.1016/j.jep.2010.09.030
Paul, S., Sarkar, S., Dutta, T., Bhattacharjee, S., 2016a. Assessment of anti-inflammatory and anti-arthritic properties of Acmella uliginosa (Sw.) Cass. based on experiments in arthritic rat models and qualitative gas chromatography-mass spectrometry analyses. J Intercult Ethnopharmacol 5, 257–262. https://doi.org/10.5455/jice.20160521010145
Paul, S., Sarkar, S., Dutta, T., Bhattacharjee, S., 2016b. Assessment of anti-inflammatory and anti-arthritic properties of Acmella uliginosa (Sw.) Cass. based on experiments in arthritic rat models and qualitative gas chromatography-mass spectrometry analyses. J Intercult Ethnopharmacol 5, 257–262. https://doi.org/10.5455/jice.20160521010145
Ramachandran, R.G., Radhakrishnan, R., Ramachandran, R.G., Radhakrishnan, R., 2020. Anatomical Characterization of Nine Taxa of Genus Acmella Rich. (Toothache Plant) in India. Brazilian Archives of Biology and Technology 63. https://doi.org/10.1590/1678-4324-2020190083
Sankar, K.G., Venkateswarlu, B.S., 2021. Free radicals scavenging aptitude of Spilanthes acmella. Research Journal of Pharmacy and Technology 14, 2631–2634. https://doi.org/10.52711/0974-360X.2021.00463
Santos, C.C. de M.P., Salvadori, M.S., Mota, V.G., Costa, L.M., de Almeida, A.A.C., de Oliveira, G.A.L., Costa, J.P., de Sousa, D.P., de Freitas, R.M., de Almeida, R.N., 2013. Antinociceptive and Antioxidant Activities of Phytol In Vivo and In Vitro Models. Neuroscience Journal 2013, 1–9. https://doi.org/10.1155/2013/949452
Sharma, R., Arumugam, N., 2021. N-alkylamides of Spilanthes (syn: Acmella): Structure, purification, characterization, biological activities and applications – a review. Future Foods 3, 100022. https://doi.org/10.1016/j.fufo.2021.100022
Sharma, R., Karunambigai, A., Gupta, S., Arumugam, N., 2021. Evaluation of biologically active secondary metabolites isolated from the toothache plant Acmella ciliata (Asteraceae). ADV TRADIT MED (ADTM). https://doi.org/10.1007/s13596-021-00584-5
Vihotogbe-Sossa, C.N.A., Akissoe, N.H., Anihouvi, V.B., Ahohuendo, B.C., Ahanchede, A., Sanni, A., Hounhouigan, D.J., 2012. Endogenous Knowledge of Four Leafy Vegetables Used by Rural Populations in Benin. Ecology of Food and Nutrition 51, 22–39. https://doi.org/10.1080/03670244.2012.635570
Downloads
Published
Issue
Section
License
Copyright (c) 2023 Jurnal Ilmiah Kesehatan Delima

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.





